lipitor grapefruit

A:Here is the exact quote on Grape fruit juice and Lipitor: "Grapefruit juice: Contains one or more components that inhibit CYP3A4 and can increase plasma concentrations of drugs metabolised by CYP3A4. Intake of one 240 ml glass of grapefruit juice resulted in an increase in Lipitor AUC of 37 % and a decreased AUC of 20.4 % for the active orthohydroxy metabolite. However, large quantities of grapefruit juice (over 1.2L daily for 5 days) increased AUC of Lipitor 2.5 fold. Concomitant intake of large quantities of grapefruit juice and Lipitor is therefore not recommended." And from this I can conclude: 1. Time of ingestion does not differ in the interaction 2. The amount of Grape fruit juice taken has an effect on the extent of interaction. 3. If you can't stop the grape fruit, you will have to monitor the cholesterol levels periodically, and you might need to adjust the dose of Lipitor accordingly. Of course, this has to be done under the supervision of your doctor.

A:I was not able to take Lipitor, it made my legs hurt. So next we tried Zocor and that worked great. It has really lowered my cholesterol! If you can do Lipitor, though, it's better. All the other statin drugs, you have to take them at bedtime, because it's during the night that your body produces cholesterol. Lipitor, you can take any time. Grapefruit won't hurt you, but if you have it in your stomach when you take Lipitor it decreases the effect of the Lipitor.

A:Avoid eating grapefruit or drinking grapefruit juice while being treated with this medication unless your doctor instructs you otherwise. Grapefruit juice can increase the amount of certain medications in your bloodstream. Consult your doctor or pharmacist for more details. Lipitor happens to be one of these drugs, and this can increase to toxic levels in your bloodstream. . Why did you not ask your doctor this when he told you?

A:Grapefuit juice happens to inhibit one of the major 'detoxification' enzymes (called cytochrome P450, isonzyme 3A4) present in the gut. Usually, this enzyme would metabolise some of the drugs that you have ingested, resulting in less of the active drug making it through to the blood stream. Pharmacologists know this - they simply compensate by increasing the dose that you swallow, so that the dose that reaches the blood stream is the correct one. If you take grapefruit juice, however, the metabolism that would occur in the gut is inhibited. This results in higher drug levels in the blood. This of course, is similar to taking a mild overdose of the particular drug, which can lead to toxicity. Hope that helps.

A:It can be a very serious problem. Please see the link below.